British Air Force Typhoon fighter aircraft have conducted a mission with French aircraft in a combined operation against an hidden munitions depot in Syrian territory employed by the IS group, according to the UK's MoD.
The site, located using reconnaissance, was thought to be storing arms and explosives, the statement said, and was located in mountainous terrain just above Palmyra in the heart of Syria.
"Our aircraft used laser-guided Paveway IV weapons to hit a series of entry passages providing entry to the site... early reports indicate the objective was successfully hit," the ministry announced.
There was no sign of any civilian casualties in the operation late on Saturday and each participating jet returned to base without incident, the defence officials confirmed.
The Typhoon FGR4s were supported by a Voyager tanker plane.
IS - alternatively referred to as Daesh - imposed extremist governance over parts of both Syria and Iraq before its territorial defeat in 2019.
"This operation underscores our UK leadership, and resolve to stand shoulder to shoulder with our allies, to stamp out any revival of the terrorist group and their violent and radical beliefs in the area," the British Defence Secretary John Healey said.
RAF aircraft have carried out surveillance missions over Syrian airspace to "forestall any attempted resurgence" of Islamic State subsequent to its defeat at the battle of Baghuz in the year 2019, the MoD reported.
"I want to thank all the members of British forces participating in this mission for their expertise and their courage," the Defence Secretary said. "They were among numerous British troops on duty over the festive period. This operation, to eliminate dangerous terrorists who pose a risk to our way of life, demonstrates how our armed forces are prepared to act, continuously, ensuring Britain's security within its borders and influential overseas."
During December, the US military conducted what it termed a "massive strike" on IS targets in Syria, after an assault resulted in the deaths of two US troops and a local interpreter in Palmyra.
The UN says Daesh still has roughly 5-7 thousand fighters in Syria and Iraq.